Abstract
HUMAN wart (papilloma) virus (HWV) is an authentic human tumour virus. Based on morphology, it has been classified as a member of the papova group1 of animal tumour viruses. Using electron microscopy, HWV has been found to be associated with human skin warts2, laryngeal and venereal papillomas3,4 and epidermodysplasia verruciformis5. Moreover, experiments done with human volunteers at the beginning of this century6–8, showed that filtered extracts of warts, laryngeal and venereal papillomas can cause skin warts in man. Since these early experiments, there has been little increase in our knowledge of HWV as a causative agent of either benign tumours or those which can progress to malignancy5,9, mainly because of the lack of a system in which to propagate HWV in vitro10. This report describes the propagation of HWV in a tissue culture system.
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EISINGER, M., KUCAROVA, O., SARKAR, N. et al. Propagation of human wart virus in tissue culture. Nature 256, 432–434 (1975). https://doi.org/10.1038/256432a0
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DOI: https://doi.org/10.1038/256432a0
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