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Activation of a voltage-insensitive conductance by inward calcium current

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Abstract

ELECTRICAL excitability is more complex in cell bodies than in axons. In various nerve cells there is a voltage-sensitive permeability to calcium as well as to sodium and potassium. Furthermore, increased calcium in the cytoplasm of nerve cell bodies increases their potassium permeability. In voltage-clamped Helix neurones, Meech and Standen1,2 reported that a substantial fraction of the potassium conductance activated during a depolarisation depends on an inward calcium current.

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References

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    Meech, R. W., and Standen, N. B., J. Physiol., Lond., 237, 43–44 (1974).

  2. 2

    Meech, R. W., and Standen, N. B., J. Physiol., Lond. (in the press).

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    Waltman, B., Acta physiol. scand., 74, 29A (1968).

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    Obara, S., and Bennett, M. V. L., J. gen. Physiol., 60, 534–557 (1972).

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    Waltman, B., Acta physiol. scand. suppl., 264, 1–60 (1966).

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    Meech, R. W., J. Physiol., Lond., 237, 259–277 (1974).

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    Fühner, H., Z. für Allgemeine Physiol., 8, 485–491 (1908).

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