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Activation of a voltage-insensitive conductance by inward calcium current

Nature volume 256, pages 425–427 (1975)Cite this article

Abstract

ELECTRICAL excitability is more complex in cell bodies than in axons. In various nerve cells there is a voltage-sensitive permeability to calcium as well as to sodium and potassium. Furthermore, increased calcium in the cytoplasm of nerve cell bodies increases their potassium permeability. In voltage-clamped Helix neurones, Meech and Standen1,2 reported that a substantial fraction of the potassium conductance activated during a depolarisation depends on an inward calcium current.

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References

  1. Meech, R. W., and Standen, N. B., J. Physiol., Lond., 237, 43–44 (1974).

    Article  Google Scholar 

  2. Meech, R. W., and Standen, N. B., J. Physiol., Lond. (in the press).

  3. Waltman, B., Acta physiol. scand., 74, 29A (1968).

    Article  Google Scholar 

  4. Obara, S., and Bennett, M. V. L., J. gen. Physiol., 60, 534–557 (1972).

    Article  CAS  Google Scholar 

  5. Waltman, B., Acta physiol. scand. suppl., 264, 1–60 (1966).

    CAS  PubMed  Google Scholar 

  6. Meech, R. W., J. Physiol., Lond., 237, 259–277 (1974).

    Article  CAS  Google Scholar 

  7. Murray, R. W., J. exp. Biol., 39, 119–128 (1962).

    CAS  PubMed  Google Scholar 

  8. Jansen, J. K. S., and Nicholls, J. G., J. Physiol., Lond., 229, 635–655 (1973).

    Article  CAS  Google Scholar 

  9. Fühner, H., Z. für Allgemeine Physiol., 8, 485–491 (1908).

    Google Scholar 

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Authors and Affiliations

  1. Albert Einstein College of Medicine, Bronx, New York, 10461

    W. CLUSIN, D. C. SPRAY & M. V. L. BENNETT

  2. Marine Biological Laboratory, Woods Hole, Massachusetts, 02543

    W. CLUSIN, D. C. SPRAY & M. V. L. BENNETT

Authors
  1. W. CLUSIN
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  2. D. C. SPRAY
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  3. M. V. L. BENNETT
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CLUSIN, W., SPRAY, D. & BENNETT, M. Activation of a voltage-insensitive conductance by inward calcium current. Nature 256, 425–427 (1975). https://doi.org/10.1038/256425a0

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  • DOI: https://doi.org/10.1038/256425a0

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