Letter | Published:

Inhibition of mobility of cell-surface receptors by factors which mediate specific cell–cell interactions



PREVIOUS studies on embryonic chick neural retina cells1 have demonstrated that cells in intact tissues or single cells prepared by mechanical dispersion have relatively little ability to redistribute their surface receptors into caps. In contrast, cells prepared by trypsinisation and dissociation of intact tissues were found to exhibit lateral redistribution of surface receptors even in the absence of a multivalent ligand. After 4 h culture, however, cells dissociated by trypsinisation have lost the capability for both spontaneus and lectin-induced rearrangements of surface components. Mobility of cell-surface receptors thus seems to be related to, or determined by, trypsin-labile components at the cell surface. One kind of component which seems to be trypsin labile is also important in intercellular recognition and adhesion2,3. We now report that the binding of tissue-type specific cell-surface ligands which seem to mediate recognition and adhesion causes inhibition of directed rearrangement of plant lectin receptors in the plane of the membrane.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1

    McDonough, J., and Lilien, J., J. Cell Sci. (in the press).

  2. 2

    Roth, S., Devl Biol., 18, 602 (1968).

  3. 3

    Lilien, J., in Curr. Top. devl Biol., 4, (edit. by Moscona, A. A., and Monroy, A.), 169 (Academic, New York, 1969).

  4. 4

    Balsamo, J., and Lilien, J., Proc. natn. Acad. Sci. U.S.A., 71, 727 (1974).

  5. 5

    Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J., J. biol. Chem., 193, 265 (1951).

  6. 6

    Edelman, G. M., Yahara, I., and Wang, J. L., Proc. natn. Acad. Sci. U.S.A., 70, 1442 (1973).

  7. 7

    Unanue, E. R., and Karnovsky, M. J., J. exp. Med., 140, 1207 (1974).

  8. 8

    Balsamo, J., and Lilien, J., Biochemistry, 14, 167 (1975).

  9. 9

    Garber, B. B., In Vitro, 8, 167 (1972).

  10. 10

    Bennet, D., Boyse, E. A., and Old, L. J., in Cell Interactions, Proceedings of the Third Lepetit Colloquium (edit. by Silvestri, L. G.), 247 (American Elsevier, New York, 1972).

Download references

Author information

Rights and permissions

To obtain permission to re-use content from this article visit RightsLink.

About this article

Further reading


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.