Letter | Published:

Inhibition of fungal growth by wheat germ agglutinin

Naturevolume 256pages414416 (1975) | Download Citation

Subjects

Abstract

GROWTH of fungal hyphae is the result of a complex and poorly understood process of cell wall synthesis and extension, that is restricted to the hyphal apex1–3. In fungi with chitin–glucan hyphal walls, such as the Deuteromycetes Trichoderma viride and Fusarium solani1, hyphal extension and septa formation involve the synthesis of chitin in hyphal tips and septa4. We therefore studied the effect on such fungi of wheat germ agglutinin (WGA), a lectin which interacts specifically with chitin oligomers5,6.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Bartnicki-Garcia, S., A. Rev. Microbiol., 22, 87–108 (1968).

  2. 2

    Girbardt, M., Protoplasma (Wien), 67, 413–441 (1969).

  3. 3

    Bartnicki-Garcia, S., Symp. Soc. gen. Microbiol., 23, 245–267 (1973).

  4. 4

    Galun, E., Archs Mikrobiol., 86, 305–314 (1972).

  5. 5

    Allen, A. K., Neuberger, A., and Sharon, N., Biochem. J., 131, 155–162 (1973).

  6. 6

    Lotan, R., and Sharon, N., Biochem. biophys. Res. Commun., 55, 1340–1346 (1973).

  7. 7

    Sharon, N., and Lis, H., Science, 177, 949–959 (1972).

  8. 8

    Lis, H., and Sharon, N., A. Rev. Biochem., 42, 541–574 (1973).

  9. 9

    Lotan, R., Gussin, A. E. S., Lis, H., and Sharon, N., Biochem. biophys. Res. Commun., 52, 656–662 (1973).

  10. 10

    Clark, H. F., and Shepard, C. C., Virology, 20, 642–644 (1965).

  11. 11

    Galun, E., and Gressel, J., Science, 151, 696–698 (1966).

  12. 12

    Lotan, R., Sharon, N., and Mirelman, D., Eur. J. Biochem. 55, 257–262 (1975).

  13. 13

    Nagata, Y., and Burger, M.M., J. biol. Chem., 249, 3116–3122 (1974).

  14. 14

    Privat, J. P., Delmotte, F., and Monsigny, M., FEBS Lett., 46, 224–228 (1974).

  15. 15

    Hamblin, J., and Kent, S. P., Nature new Biol., 245, 28–30 (1973).

  16. 16

    Bohlool, B. B., and Schmidt, E. L., Science, 185, 269–271 (1974).

Download references

Author information

Affiliations

  1. Departments of Biophysics and Plant Genetics, The Weizmann Institute of Science, Rehovot, Israel

    • DAVID MIRELMAN
    • , ESRA GALUN
    • , NATHAN SHARON
    •  & REUBEN LOTAN

Authors

  1. Search for DAVID MIRELMAN in:

  2. Search for ESRA GALUN in:

  3. Search for NATHAN SHARON in:

  4. Search for REUBEN LOTAN in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/256414a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.