Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Inhibition of fungal growth by wheat germ agglutinin


GROWTH of fungal hyphae is the result of a complex and poorly understood process of cell wall synthesis and extension, that is restricted to the hyphal apex1–3. In fungi with chitin–glucan hyphal walls, such as the Deuteromycetes Trichoderma viride and Fusarium solani1, hyphal extension and septa formation involve the synthesis of chitin in hyphal tips and septa4. We therefore studied the effect on such fungi of wheat germ agglutinin (WGA), a lectin which interacts specifically with chitin oligomers5,6.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. Bartnicki-Garcia, S., A. Rev. Microbiol., 22, 87–108 (1968).

    Article  CAS  Google Scholar 

  2. Girbardt, M., Protoplasma (Wien), 67, 413–441 (1969).

    Article  Google Scholar 

  3. Bartnicki-Garcia, S., Symp. Soc. gen. Microbiol., 23, 245–267 (1973).

    Google Scholar 

  4. Galun, E., Archs Mikrobiol., 86, 305–314 (1972).

    Article  CAS  Google Scholar 

  5. Allen, A. K., Neuberger, A., and Sharon, N., Biochem. J., 131, 155–162 (1973).

    Article  CAS  Google Scholar 

  6. Lotan, R., and Sharon, N., Biochem. biophys. Res. Commun., 55, 1340–1346 (1973).

    Article  CAS  Google Scholar 

  7. Sharon, N., and Lis, H., Science, 177, 949–959 (1972).

    Article  ADS  CAS  Google Scholar 

  8. Lis, H., and Sharon, N., A. Rev. Biochem., 42, 541–574 (1973).

    Article  CAS  Google Scholar 

  9. Lotan, R., Gussin, A. E. S., Lis, H., and Sharon, N., Biochem. biophys. Res. Commun., 52, 656–662 (1973).

    Article  CAS  Google Scholar 

  10. Clark, H. F., and Shepard, C. C., Virology, 20, 642–644 (1965).

    Article  Google Scholar 

  11. Galun, E., and Gressel, J., Science, 151, 696–698 (1966).

    Article  ADS  CAS  Google Scholar 

  12. Lotan, R., Sharon, N., and Mirelman, D., Eur. J. Biochem. 55, 257–262 (1975).

    Article  CAS  Google Scholar 

  13. Nagata, Y., and Burger, M.M., J. biol. Chem., 249, 3116–3122 (1974).

    CAS  PubMed  Google Scholar 

  14. Privat, J. P., Delmotte, F., and Monsigny, M., FEBS Lett., 46, 224–228 (1974).

    Article  CAS  Google Scholar 

  15. Hamblin, J., and Kent, S. P., Nature new Biol., 245, 28–30 (1973).

    Article  CAS  Google Scholar 

  16. Bohlool, B. B., and Schmidt, E. L., Science, 185, 269–271 (1974).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

MIRELMAN, D., GALUN, E., SHARON, N. et al. Inhibition of fungal growth by wheat germ agglutinin. Nature 256, 414–416 (1975).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing