Abstract
A survey of the commonest amino acids formed in prebiotic conditions suggests that the earliest form of genetic coding may have specified polypeptides with a strong tendency to form stable β-sheet structures. Poly(Val-Lys), like other polypeptides in which hydro-phobic and hydrophilic residues alternate, tends to form β structures. We show that bilayers with a hydrophobic interior and a hydrophilic exterior may be present in aqueous solution.
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References
Miller, S. L., and Orgel, L. E., in The Origins of Life on the Earth (Prentice-Hall, Englewood Cliffs, New Jersey, 1974).
Chou, P. Y., and Fasman, G. D., Biochemistry, 13, 222–245 (1974).
Woese, C., in The Genetic Code (Harper and Row, New York, 1967).
Dickerson, R. E., J. molec. Biol., 57, 1–15 (1971).
Orgel, L. E., Isr. J. Chem., 10, 287–292 (1972).
Johnson, B. J., J. pharm. Sci., 63, 313–327 (1974).
Rippon, W. B., Chen, H. H., and Walton, A. G., J. molec. Biol., 75, 369–375 (1973).
Trudelle, Y., Polymer, 16, 9–15 (1975).
Seipke, G., Arfmann, H. A., and Wagner, K. G., Biopolymers, 13, 1621–1633 (1974).
Peggion, E., Cosani, A., Terbojevich, M., and Borin, G., Biopolymers, 11, 633–643 (1972).
Marsh, R. E., Corey, R. B., and Pauling, L., Biochim. biophys. Acta, 16, 1–34 (1955).
Fraser, R. D. B., MacRae, T. P., Stewart, F. H. C., and Suzuki, E., J. molec. Biol., 11, 706–712 (1965).
Lucas, F., and Rudall, K. M., in Comprehensive Biochemistry (edit. by Florkin, M., and Stotz, F. H.), 26 B, ch. 7 (Elsevier, Amsterdam, 1968).
Iizuka, E., and Yang, J. T., Proc. natn. Acad. Sci. U.S.A., 55, 1175–1182 (1966).
Fraser, R. D. B., Harrap, B. S., MacRae, T. P., Stewart, F. H. C., and Suzuki, E., J. molec. Biol., 12, 482–490 (1965).
Fraser, R. D. B., and MacRae, T. P., in Conformation in Fibrous Proteins (edit. by Horecker, B., Kaplan, N. O., Marmur, J., and Scheraga, H. A.), ch. 10 (Academic, New York, 1973).
Padden, F. J., Jr, Keith, H. D., and Giannoni, G., Biopolymers, 7, 793–804 (1969).
Astbury, W. T., Dalgliesh, C. E., Darmon, S. E., and Sutherland, G. B. B. M., Nature, 162, 596–600 (1948).
Ananthanarayanan, V. S., J. scient. ind. Res., 31, 593–612 (1972).
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Brack, A., Orgel, L. β structures of alternating polypeptides and their possible prebiotic significance. Nature 256, 383–387 (1975). https://doi.org/10.1038/256383a0
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DOI: https://doi.org/10.1038/256383a0
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