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Three-dimensional structure, function and genetic control of immunoglobulins

Nature volume 256, pages 373–376 (1975)Cite this article

Abstract

Recent crystallographic analyses of the three-dimensional structure of immunoglobulins have shown how it is related to their binding affinities. Considered with evidence from sequencing, it is beginning to cast some light on how the genetics of immunoglobulins could have evolved to maximise binding diversity with a minimal genetic load.

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Authors and Affiliations

  1. Department of Biophysics, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205

    Roberto J. Poljak

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  1. Roberto J. Poljak
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Poljak, R. Three-dimensional structure, function and genetic control of immunoglobulins. Nature 256, 373–376 (1975). https://doi.org/10.1038/256373a0

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