Article | Published:

Three-dimensional structure, function and genetic control of immunoglobulins

Naturevolume 256pages373376 (1975) | Download Citation

Subjects

Abstract

Recent crystallographic analyses of the three-dimensional structure of immunoglobulins have shown how it is related to their binding affinities. Considered with evidence from sequencing, it is beginning to cast some light on how the genetics of immunoglobulins could have evolved to maximise binding diversity with a minimal genetic load.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Krause, R. M., Adv. Immun., 12, 1 (1970).

  2. 2

    Hill, R. L., Delaney, R., Fellows, R. E., Jr, and Lebowitz, H. E., Proc. natn. Acad. Sci. U.S.A., 56, 1762 (1966).

  3. 3

    Kabat, E. A., and Wu, T. T., Ann. N. Y. Acad. Sci., 190, 382 (1971).

  4. 4

    Oudin, J., J. Cell. Physiol., 67, suppl. 1, 77 (1966).

  5. 5

    Kunkel, H. G., Mannick, M., and Williams, R. C., Jr, Science, 140, 1218 (1963).

  6. 6

    Poljak, R. J., Amzel, L. M., Avey, H. P., Becka, L. N., and Nisonoff, A., Nature new Biol., 235, 137 (1972).

  7. 7

    Poljak, R. J., et al., Proc. natn. Acad. Sci. U.S.A., 70, 3305 (1973).

  8. 8

    Poljak, R. J., Amzel, L. M., Chen, B. L., Phizackerley, R. P., and Saul, F., Proc. natn. Acad. Sci. U.S.A., 71, 3440 (1974).

  9. 9

    Schiffer, M., Girling, R. L., Ely, K. R., and Edmundson, A. B., Biochemistry, 12, 4620 (1973).

  10. 10

    Segal, D. M., et al., Proc. natn. Acad. Sci. U.S.A., 71, 4298 (1974).

  11. 11

    Epp, O., Colman, P., Fehlhammer, H., Bode, W., Schiffer, M., and Huber, R., Eur. J. Biochem., 45, 513 (1974).

  12. 12

    Yguerabide, J., Epstein, H. F., and Stryer, L., J. molec. Biol., 51, 573 (1970).

  13. 13

    Dorrington, K. J., and Tanford, C., Adv. Immun., 12, 333 (1970).

  14. 14

    Capra, D. J., and Kehoe, J. M., J. Immun., 114, 678 (1975).

  15. 15

    Stevenson, G. T., and Mole, L. E., Biochem. J., 139, 369 (1974).

  16. 16

    Poljak, R. J., Amzel, L. M., Chen, B. L., Phizackerley, R. P., and Saul, F., Immunogenetics (in the press).

  17. 17

    Weigert, M. G., Cesari, I. M., Yonkovich, S. J., and Cohn, M., Nature, 228, 1045 (1970).

  18. 18

    Potter, M., Semin. Hematol., 10, 19 (1973).

  19. 19

    Seligman, M., and Brouet, J. C., Semin. Hematol., 10, 163 (1973).

  20. 20

    Varga, J. M., Lande, S., and Richards, F. F., J. Immun., 112, 1565 (1974).

  21. 21

    Amzel, L. M., Poljak, R. J., Saul, F., Varga, J., and Richards, F. F., Proc. natn. Acad. Sci. U.S.A., 71, 1427 (1974).

  22. 22

    Edmundson, A. B., et al., Biochemistry, 13, 3816 (1974).

  23. 23

    Michaelides, M. C., and Eisen, H. N., J. exp. Med., 140 687 (1974).

  24. 24

    Richards, F. F., Konigsberg, W. H., Rosenstein, R. W., and Varga, J. M., Science, 187, 130 (1975).

  25. 25

    Poljak, R. J., Amzel, L. M., Chen, B. L., Phizackerley, R. P., and Saul, F., Proc. R. Soc., B (in the press).

  26. 26

    Wolfenstein-Todel, C., Mihaesco, E., and Frangione, B., Proc. natn. Acad. Sci. U.S.A., 71 974 (1974).

  27. 27

    Milstein, C., Adetugbo, K., Cowan, W. J., and Secher, D. S., Progr. Immun., (edit. by Brent, L., and Holborow, E. J.), 2, 157 (North Holland, Amsterdam, 1974).

  28. 28

    Preud'homme, J. L., Birshtein, B. K., and Scharff, M. D., Proc. natn. Acad. Sci. U.S.A., 72, 1427 (1975).

  29. 29

    Florent, G., Lehman, D., and Putnam, F. W., Biochemistry, 13, 2482 (1974).

  30. 30

    Peterson, P. A., Cunningham, B. A., Berggard, I., and Edelman, G. M., Proc. natn. Acad. Sci. U.S.A., 69, 1697 (1972).

  31. 31

    Peterson, P. A., Rask, L., Sege, K., Klareskog, L., Anundi, H., and Ostberg, L., Proc. natn. Acad. Sci. U.S.A., 72, 1612 (1975).

  32. 32

    Richardson, J. S., Thomas, K. A., Rubin, B. H., and Richardson, D. C., Proc. natn Acad. Sci. U.S.A., 72, 1349 (1975).

  33. 33

    Poljak, R. J., Contemporary Topics in Molecular Immunology, 2 (edit. by Reisfeld, R. A., and Mandy, W. J.), 1 (Plenum, New York, 1973).

  34. 34

    Gally, J. A., and Edelman, G. M., A. Rev. Genet., 6, 1 (1972).

Download references

Author information

Affiliations

  1. Department of Biophysics, Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205

    • Roberto J. Poljak

Authors

  1. Search for Roberto J. Poljak in:

About this article

Publication history

Issue Date

DOI

https://doi.org/10.1038/256373a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.