Letter | Published:

Possible role for poly(A) as an inhibitor of endonuclease activity in eukaryotic cells

Naturevolume 256pages340342 (1975) | Download Citation

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Abstract

A NUMBER of laboratories have reported the isolation from eukaryotic cells of mRNAs linked covalently at their 3′-OH termini to polyadenylic add (poly(A))1–4. The chain of adenylic acid residues has been found also at the 3′ termini of RNAs isolated from several well characterised viruses5–7. Although considerable evidence exists to suggest that the insertion of poly(A) on the RNA chains destined to become mRNA is a post-transcriptional event8, there is at present little understanding of the part poly(A) plays in the subsequent stages of protein synthesis.

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Affiliations

  1. Enzymology and Drug Metabolism Section, Laboratory of Pharmacology, Baltimore Cancer Research Center, National Cancer Institute, National Institute of Health, Baltimore, Maryland, 21211

    • CARL C. LEVY
    • , MORTON SCHMUKLER
    • , JOSEPH J. FRANK
    • , TIMOTHY P. KARPETSKY
    • , PHILLIP B. JEWETT
    • , PHILIP A. HIETER
    • , STEPHEN M. LEGENDRE
    •  & ROBERT G. DORR

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https://doi.org/10.1038/256340a0

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