Letter | Published:

N-terminal sequences of secretory piece and of α chains of different allotype in rabbit secretory IgA

Naturevolume 256pages339340 (1975) | Download Citation



THE translocation hypothesis1,2 states that in the process of antibody synthesis any one of a number of immunoglobulin heavy chain V genes is available for union with any of the class-specific C genes. Whereas almost all structural data support the widely held view that all V genes are able to translocate to any of the class-specific C genes, some data suggest that this may not be the case. Wilkinson3 found the N-terminal sequence PCA–Ser–Ser (PCA, pyrrolidone carboxylic acid) to be present in a rabbit α chain preparation but absent in pooled rabbit γ chains. Other workers4,5 have described an N-terminal heavy chain sequence apparently confined to the IgM class of human immunoglobulins.

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  1. MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, OX1 3QU, UK



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