Abstract
THE translocation hypothesis1,2 states that in the process of antibody synthesis any one of a number of immunoglobulin heavy chain V genes is available for union with any of the class-specific C genes. Whereas almost all structural data support the widely held view that all V genes are able to translocate to any of the class-specific C genes, some data suggest that this may not be the case. Wilkinson3 found the N-terminal sequence PCA–Ser–Ser (PCA, pyrrolidone carboxylic acid) to be present in a rabbit α chain preparation but absent in pooled rabbit γ chains. Other workers4,5 have described an N-terminal heavy chain sequence apparently confined to the IgM class of human immunoglobulins.
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JOHNSTONE, A., MOLE, L. N-terminal sequences of secretory piece and of α chains of different allotype in rabbit secretory IgA. Nature 256, 339–340 (1975). https://doi.org/10.1038/256339a0
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DOI: https://doi.org/10.1038/256339a0
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