Letter | Published:

Appearance of hypoxanthine guanine phosphoribosyltransferase activity as a consequence of mycoplasma contamination

Naturevolume 256pages329331 (1975) | Download Citation



MYCOPLASMAS are common contaminants of cells in culture and are often responsible for profound alterations in the metabolism of infected cells1,2. Such alterations include chromosomal aberrations3,4 and changes in host cell enzyme activities5. We have reported that amniotic fluid cell cultures contaminated with mycoplasmas revealed a significant increase in chromosomal aberrations over those seen in uninfected cultures6. This finding demonstrated that the presence of these organisms in amniotic fluid cell lines poses a potential hazard to prenatal chromosome diagnosis.

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  1. Department of Medical Microbiology, Stanford University School of Medicine, Stanford, California, 94305

  2. Department of Biology, Case Western Reserve University, Cleveland, Ohio, 44106

  3. Laboratory of Cellular and Comparative Physiology, NIA, NIH, DHEW and Baltimore City Hospitals, Baltimore, Maryland, 21224



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