Letter | Published:

Internal regulation of iron absorption

Naturevolume 256pages328329 (1975) | Download Citation

Subjects

Abstract

MCCANCE and Widdowson1 concluded that body iron content is regulated by variation in the amount absorbed and not by variation in excretion, and many workers have since attempted to define the factors which relate iron absorption to the needs of the body. Although there is a large body of data on the intracellular mechanisms of absorption2 this has not advanced our understanding of the physiology of regulation.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    McCance, R. A. and Widdowson, E. M. Lancet, ii, 680–684 (1937).

  2. 2

    Turnbull, A., in Iron in Biochemistry and Medicine (edit. by Jacobs, A., and Worwood, M.), 369–403 (Academic, London and New York, 1974).

  3. 3

    Crosby, W. H. Blood, 22, 441–449 (1963).

  4. 4

    Pinkerton, P. H. Ann. Int. Med., 70, 401–408 (1969).

  5. 5

    Jacobs, A., in Clinics in Haematology, 2, no. 2, (edit. by Callender, S. T.), 323–337 (Saunders, London 1973).

  6. 6

    Weintraub, L. R., Conrad, M. E. and Crosby, W. H. Blood, 24, 19–24 (1964).

  7. 7

    Fletcher, J. and Huehns, E. R. Nature, 218, 1211–1214 (1968).

  8. 8

    Conrad, M. E. Gastroenterology, 57, 225–228 (1969).

  9. 9

    Conrad, M. E., Weintraub, L. R. and Crosby, W. H. J. clin. Invest., 43, 963–974 (1964).

  10. 10

    Balcerzak, S. P. and Greenberger, N. J. Nature, 220, 270–271 (1968).

  11. 11

    Richmond, V. S., Worwood, M. and Jacobs, A. Br. J. Haemat., 14, 605–614 (1972).

  12. 12

    Mattii, R., Mielke, C. H., Levine, P. H. and Crosby, W. H. Blood, 42, 959–966 (1973).

  13. 13

    Brittin, G. M. and Raval, D. J. Lab. clin. Med., 75, 811–817 (1970).

  14. 14

    Cook, J. D., Lipschitz, D. A., Miles, L. E. M. and Finch, C. A. Am. J. din. Nutrit., 27, 681–687 (1974).

  15. 15

    Walters, G. O., Jacobs, A., Worwood, M., Trevett, D. and Thomson, W. Gut, 16, 188–192 (1975).

  16. 16

    Crosby, W. H., in Regulation of Hematopoiesis, 1 (edit. by Gordon, A. S.), 519–537 (Appleton–Century–Crofts, New York, 1970).

Download references

Author information

Affiliations

  1. Department of Haematology, Welsh National School of Medicine, Cardiff, UK

    • I. CAVILL
    • , M. WORWOOD
    •  & A. JACOBS

Authors

  1. Search for I. CAVILL in:

  2. Search for M. WORWOOD in:

  3. Search for A. JACOBS in:

About this article

Publication history

Received

Accepted

Issue Date

DOI

https://doi.org/10.1038/256328a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.