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Morphology and biochemistry of small, intensely fluorescent cells of sympathetic ganglia

Naturevolume 256pages315317 (1975) | Download Citation

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Abstract

NEURAL transmission in sympathetic ganglia has been regarded as an automatic relay involving only pre- and postganglionic neurones. It is now agreed, however, that the small, intensely fluorescent cells — at least some of which are interneurones1,2 — modulate transmission in the superior cervical ganglion. Greengard et al.3–6 have documented the role of the ganglionic interneurone in modulating ganglionic transmission. Dopamine released from an interneurone binds to a receptor on the surface of the ganglionic neurone, activating an adenylate cyclase. The increased production of cyclic AMP leads to hyperpolarisation of the ganglionic neurone by a mechanism which is still obscure.

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  1. Department of Anatomy, University of Iowa, Iowa City, Iowa, 52242

    • T. H. WILLIAMS
    • , A. C. BLACK JR
    • , T. CHIBA
    •  & R. C. BHALLA

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https://doi.org/10.1038/256315a0

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