Abstract
NEURAL transmission in sympathetic ganglia has been regarded as an automatic relay involving only pre- and postganglionic neurones. It is now agreed, however, that the small, intensely fluorescent cells — at least some of which are interneurones1,2 — modulate transmission in the superior cervical ganglion. Greengard et al.3–6 have documented the role of the ganglionic interneurone in modulating ganglionic transmission. Dopamine released from an interneurone binds to a receptor on the surface of the ganglionic neurone, activating an adenylate cyclase. The increased production of cyclic AMP leads to hyperpolarisation of the ganglionic neurone by a mechanism which is still obscure.
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WILLIAMS, T., BLACK, A., CHIBA, T. et al. Morphology and biochemistry of small, intensely fluorescent cells of sympathetic ganglia. Nature 256, 315–317 (1975). https://doi.org/10.1038/256315a0
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DOI: https://doi.org/10.1038/256315a0
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