Abstract
OUR previous report1 provided evidence for the existence of the brain-specific nuclear RNA using the RNA–DNA hybridisation method. As the neuronal and glial cells in the brain possess specific compositions and functions, each of these cells probably contains cell-specific RNA, as suggested by Church and Brown2. In fact, Hydén et al.3 found remarkable differences in base composition between the total RNA of neuronal and glial cells. This difference may be accounted for by a greater proportion of cytoplasmic (ribosomal) RNA present in the neurone4. This report provides new evidence for the existence of cell-specific RNA in brain, using a unique DNA–3H-RNA hybridisation method.
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SOGA, K., TAKAHASHI, Y. Differences in transcription of unique DNA sequences between neuronal and glial cells. Nature 256, 233–234 (1975). https://doi.org/10.1038/256233a0
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DOI: https://doi.org/10.1038/256233a0
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