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Induction of erythroid leukaemia by Harvey and Kirsten sarcoma viruses

Abstract

SEVERAL RNA tumour viruses including the Friend1, Rauscher2 and Kirsten (MLV-Ki)3 strains cause erythroid leukaemia in mice. These agents do not transform cells in vitro, but provide a helper activity for the replication of defective transforming sarcoma viruses. The Kirsten sarcoma virus (KiSV)4 was isolated from a rat inoculated with MLV-Ki, whereas the Harvey sarcoma virus (HaSV)5 was recovered from a rat infected with the non-transforming Moloney leukaemia helper virus (MLV-M)6. Both sarcoma viruses contain common rat genetic sequences7,8.

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