Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Murine sarcoma virus pseudotypes acquire a determinant specifying N or B tropism from leukaemia virus during rescue

Nature volume 256, pages 223–225 (1975)Cite this article

Abstract

SEVERAL classes of murine leukaemia viruses (MuLV) are recognised according to their ability to induce XC plaque formation with high or low efficiency after infection of various mouse cell lines1,2. N- and B-tropic MuLVs, for example, can be distinguished on the basis of their relative ability to infect N-type or B-type mouse cells, the cells themselves differing at a single genetic locus, Fv-1 (ref. 3). Fv-1 restriction is not absolute1, is dominant over susceptibility in F1 hybrids4, and may be mediated by a specific intracellular inhibitor5,6. Studies using vesicular stomatitis virus (VSV) pseudotypes made with N- or B-tropic MuLV have shown that Fv-1 restriction occurs after virus penetration7,8, although the mechanism of inhibition is not known. A clear difference exists between Fv-1 restriction of MuLV and the host range restriction of avian leukaemia virus subgroups, in which host range restriction occurs at the cell surface9,10. Another class of MuLVs, NB-tropic, does not seem to be sensitive to Fv-1-mediated restriction1.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Hartley, J. W., Rowe, W. P., and Huebner, R. J., J. Virol., 5, 221–225 (1970).

    PubMed  PubMed Central  CAS  Google Scholar 

  2. Levy, J. A., Science, 182, 1151–1153 (1973).

    Article  ADS  CAS  PubMed  Google Scholar 

  3. Pincus, T., Rowe, W. P., and Lilly, F., J. exp. Med, 133, 1234–1241 (1971).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Pincus, T., Hartley, J. W., and Rowe, W. P., J. exp. Med., 133, 1219–1233 (1971).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Tennant, R. W., Myer, F. E., and McGrath, L., Int. J. Cancer, 14, 504–513 (1974).

    Article  CAS  PubMed  Google Scholar 

  6. Tennant, R. W., Schluter, B., Yang, W-K., and Brown, A., Proc. natn. Acad. Sci. U.S.A., 71, 4241–4245 (1974).

    Article  ADS  CAS  Google Scholar 

  7. Krontiris, T. G., Soeiro, R., and Fields, B. N., Proc. natn. Acad. Sci. U.S.A., 70, 2549–2553 (1973).

    Article  ADS  CAS  Google Scholar 

  8. Huang, A. S., Besmer, P., Chu, L., and Baltimore, D., J. Virol., 12, 659–662 (1973).

    PubMed  PubMed Central  CAS  Google Scholar 

  9. Piraino, F., Virology, 32, 700–707 (1967).

    Article  CAS  PubMed  Google Scholar 

  10. Crittenden, L. B., J. natn. Cancer Inst., 41, 145–153 (1968).

    CAS  Google Scholar 

  11. Huebner, R. J., and Todaro, G. J., Proc. natn. Acad. Sci. U.S.A., 64, 1087–1094 (1969).

    Article  ADS  CAS  Google Scholar 

  12. Harvey, J. J., and East, J., Int. Rev. exp. Path., 10, 265–360 (1971).

    PubMed  CAS  Google Scholar 

  13. Aaronson, S. A., and Rowe, W. P., Virology, 42, 9–19 (1970).

    Article  CAS  PubMed  Google Scholar 

  14. Bassin, R. H. Tuttle, N., and Fischinger, P. J., Int. J. Cancer, 6, 95–107 (1970).

    Article  CAS  PubMed  Google Scholar 

  15. Fischinger, P. J., and O'Connor, T. E., Science, 165, (714–719). 1966

    Article  ADS  Google Scholar 

  16. Huebner, R. J., Hartley, J. W., Rowe, W. P., Lane, W. T., and Capps, W. I., Proc. natn. Acad. Sci. U.S.A., 56, 1164–1169 (1966).

    Article  ADS  CAS  Google Scholar 

  17. Gomard, E., Leclerc, J. C., and Levy, J. P., J. natn. Cancer Inst., 50, 955–961 (1973).

    Article  CAS  Google Scholar 

  18. Aaronson, S. A., and Todaro, G. J., J. cell Physiol, 72, 141–148 (1968).

    Article  CAS  PubMed  Google Scholar 

  19. Reznikoff, C. A., Brankow, D. W., and Heidelberger, C., Cancer Res., 33, 3231–3238 (1973).

    PubMed  CAS  Google Scholar 

  20. Gisselbrecht, S., Bassin, R. H., Gerwin, B. I., and Rein, A., Int. J. Cancer, 14, 106–113 (1974).

    Article  CAS  PubMed  Google Scholar 

  21. Yoshikura, H., J. gen. Virol., 19, 321–327 (1973).

    Article  CAS  PubMed  Google Scholar 

  22. Hartley, J. W., and Rowe, W. P., Proc. natn. Acad. Sci. U.S.A., 55, 780–786 (1966).

    Article  ADS  CAS  Google Scholar 

  23. Aaronson, S. A., Jainchill, J. L., and Todaro, G. J., Proc. natn. Acad. Sci. U.S.A., 66, 1236–1243 (1970).

    Article  ADS  CAS  Google Scholar 

  24. Aaronson, S. A., and Weaver, C. A., J. gen. Virol., 13, 245–252 (1971).

    Article  CAS  PubMed  Google Scholar 

  25. Love, D. N., and Weiss, R. A., Virology, 57, 271–278 (1974).

    Article  CAS  PubMed  Google Scholar 

  26. Stephenson, J. R., and Aaronson, S. A., Virology, 58, 294–297 (1974).

    Article  CAS  PubMed  Google Scholar 

  27. Varmus, H. E., Vogt, P. K., and Bishop, J. M., Proc. natn. Acad. Sci. U.S.A., 70, 3067–3071 (1973).

    Article  ADS  CAS  Google Scholar 

  28. Peebles, P. T., et al., J. Virol., 8, 690–694 (1971).

    PubMed  PubMed Central  CAS  Google Scholar 

  29. Fischinger, P. J., Moore, C. O., and O'Connor, T. E., J. natn. Cancer Inst., 42, 605–622 (1969).

    CAS  Google Scholar 

  30. Rowe, W. P., Pugh, W. E., and Hartley, J. W., Virology, 42, 1136–1139 (1970).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Author notes

  1. SYLVIANE GISSELBRECHT

    Present address: Service d'Hematologie, Hôpital Cochin, 27 Faubourg Saint-Jacques, 75–014, Paris, France

Authors and Affiliations

  1. Viral Leukemia and Lymphoma Branch, National Cancer Institute, Bethesda, Maryland, 20014

    ROBERT H. BASSIN, GRACIELA DURAN-TROISE, BRENDA I. GERWIN & SYLVIANE GISSELBRECHT

  2. Litton Bionetics Inc., 7300 Pearl Street, Bethesda, Maryland, 20014

    ALAN REIN

Authors
  1. ROBERT H. BASSIN
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. GRACIELA DURAN-TROISE
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. BRENDA I. GERWIN
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. SYLVIANE GISSELBRECHT
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. ALAN REIN
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

BASSIN, R., DURAN-TROISE, G., GERWIN, B. et al. Murine sarcoma virus pseudotypes acquire a determinant specifying N or B tropism from leukaemia virus during rescue. Nature 256, 223–225 (1975). https://doi.org/10.1038/256223a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/256223a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing