THE response of the rat pituitary gland to oestrogen includes increased mitotic and secretory activity affecting several of the cell types in the anterior lobe but leading in particular to proliferation of prolactin cells1. Bromocryptine inhibits release of prolactin2,3 and also inhibits DNA synthesis in the oestrogen-stimulated pituitary gland4. In studying the pituitary response to oestrogen during a prolonged period of bromocryptine inhibition, we have observed a close relationship between effects on serum prolactin levels and on pituitary mitotic activity. Our findings lend support to the idea that secretory behaviour influences mitotic activity in prolactin cells4.
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LLOYD, H., MEARES, J. & JACOBI, J. Effects of oestrogen and bromocryptine on in vivo secretion and mitosis in prolactin cells. Nature 255, 497–498 (1975). https://doi.org/10.1038/255497a0
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