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Effects of oestrogen and bromocryptine on in vivo secretion and mitosis in prolactin cells


THE response of the rat pituitary gland to oestrogen includes increased mitotic and secretory activity affecting several of the cell types in the anterior lobe but leading in particular to proliferation of prolactin cells1. Bromocryptine inhibits release of prolactin2,3 and also inhibits DNA synthesis in the oestrogen-stimulated pituitary gland4. In studying the pituitary response to oestrogen during a prolonged period of bromocryptine inhibition, we have observed a close relationship between effects on serum prolactin levels and on pituitary mitotic activity. Our findings lend support to the idea that secretory behaviour influences mitotic activity in prolactin cells4.

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  1. Gersten, B. E., and Baker, B. L., Am. J. Anat., 128, 1–20 (1970).

    Article  CAS  Google Scholar 

  2. Pasteels, J. L., Danguy, A., Frerotte, M., and Ectors, F., Annls Endocr., 32, 188–192 (1971).

    CAS  Google Scholar 

  3. Shaar, C. J., and Clemens, J. A., Endocrinology, 90, 285–288 (1972).

    Article  CAS  Google Scholar 

  4. Davies, C., Jacobi, J., Lloyd, H. M., and Meares, J. D., J. Endocr., 61, 411–417 (1974).

    Article  CAS  Google Scholar 

  5. Lemay, A., and Labrie, F., FEBS Lett., 20, 7–10 (1972).

    Article  CAS  Google Scholar 

  6. Nagasawa, H., and Yanai, R., J. Endocr., 55, 215–216 (1972).

    Article  CAS  Google Scholar 

  7. Masui, H., and Garren, L. D., Proc. natn. Acad, Sci. U.S.A., 68, 3206–3210 (1971).

    Article  ADS  CAS  Google Scholar 

  8. Burger, M. M., Bombik, B. M., Breckenridge, B. McL., and Sheppard, J. R., Nature, 239, 161–163 (1972).

    Article  CAS  Google Scholar 

  9. Hymer, W. C., Mastro, A., and Griswold, E., Science, 167, 1629–1631 (1970).

    Article  ADS  CAS  Google Scholar 

  10. Meites, J., and Clemens, C. W., Vitam. Horm., 30, 165–221 (1972).

    Article  CAS  Google Scholar 

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LLOYD, H., MEARES, J. & JACOBI, J. Effects of oestrogen and bromocryptine on in vivo secretion and mitosis in prolactin cells. Nature 255, 497–498 (1975).

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