Abstract
TREATMENT of the laboratory mouse with Corynebacterium parvum can potentiate efficacy of host reaction against tumours1–4. This has been reflected in the proportion of mice whose tumours: (1) grew more slowly; (2) regressed partially before continuing growth, and (3) regressed completely, either temporarily or permanently. Furthermore, in some mouse tumour systems chemotherapy is more effective when hosts are stimulated with C. parvum. We have now found that administration of C. parvum before local irradiation of 8-mm diameter fibrosarcoma isotransplants increases the frequency of cure, strikingly so after low radiation doses.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Halpern, B. N., Biozzi, G., Stiffel, C., and Mouton, D., Nature, 212, 853–854 (1966).
Woodruff, M. F. A., and Boak, J. L., Br. J. Cancer, 20, 345–355 (1966).
Milas, L., and Mujagic, H., Eur. J. clin. biol. Res., 17, 498–500 (1972).
Fisher, J. C., Grace, W. R., and Mannick, J. A., Cancer, 26, 1379–1382 (1970).
Amiel, J. L., and Bernardet, M., Eur. J. Cancer, 6, 557–559 (1970).
Currie, G. A. and Bagshawe, K. D., Br. med. J., 1, 541–544 (1970).
Pearson, J. W., Pearson, G. R., Gibson, W. T., Chermann, J. C., and Chirigos, M. A., Cancer Res., 32, 904–907 (1972).
Jurin, M., and Suit, H., Cancer Res., 32, 2201–2211 (1972).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
SUIT, H., SEDLACEK, R., WAGNER, M. et al. Radiation response of C3H fibrosarcoma enhanced in mice stimulated by Corynebacterium parvum. Nature 255, 493–494 (1975). https://doi.org/10.1038/255493a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/255493a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
