Abstract
IT is well known that in certain conditions the growth of allogeneic tumours can be enhanced by passively transferred antibodies directed against antigens present on the graft1,2. Most of the hypotheses proposed to explain this phenomenon have placed some form of antibody-mediated interference with the immune response of the host towards the tumour. Nevertheless, there have been occasional observations which suggest that immunological enhancement is the result of a change in the neoplastic cells themselves resulting from the interaction with antibody3–5. We have reported the results of in vitro experiments which support this idea6. Nucleoside incorporation, DNA synthesis, and cell growth were stimulated when mouse L cells were incubated in the presence of limiting amounts of rabbit anti-L cell serum (aLS); higher concentrations of antibody inhibited cell growth. Addition of complement greatly augmented cell growth, especially at low concentrations of antibody7. We now report that this immunostimulation phenomenon can also be observed in vivo. A preliminary report of this work has appeared8.
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FINK, M., PARKER, C. & SHEARER, W. Antibody stimulation of tumour growth in T-cell depleted mice. Nature 255, 404–405 (1975). https://doi.org/10.1038/255404a0
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DOI: https://doi.org/10.1038/255404a0
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