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Modified nucleosides and bizarre 5′-termini in mouse myeloma mRNA

Nature volume 255, pages 28–33 (1975)Cite this article

Abstract

Messenger RNAs from mouse myeloma cells contain N6-methyl adenosine and novel 5′ termini having 7-methylguanosine in a 5′, 5′triphosphate linkage with ribose-methylated nucleosides. Ten common 5′-terminal sequences of the forms m7G5′ppp5′NmpNp and m7G5′ppp5′NmpNmpNp are reported. Structures like this may be a general feature of mRN A in eukaryotes.

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Authors and Affiliations

  1. The Walter and Eliza Hall Institute of Medical Research, PO, Royal Melbourne Hospital, Victoria, 3050, Australia

    Jerry M. Adams & Suzanne Cory

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  1. Jerry M. Adams
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  2. Suzanne Cory
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Adams, J., Cory, S. Modified nucleosides and bizarre 5′-termini in mouse myeloma mRNA. Nature 255, 28–33 (1975). https://doi.org/10.1038/255028a0

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  • DOI: https://doi.org/10.1038/255028a0

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