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Symmetrical transcription of herpes simplex virus DNA in infected BSC-1 cells


ALONI1–3 reported that late in the replicative cycle of polyoma and simian virus 40 (SV40) viruses the viral DNA genomes are symmetrically transcribed in the infected cells. The newly synthesised RNA molecules labelled for very short periods were shown to be complementary and on self-annealing yielded high molecular weight double stranded (ds) RNA. Aloni and Attardi showed that similar symmetrical transcription occurs in HeLa cell mitochondria4,5. In further studies Aloni2 demonstrated that after polyadenylation of the SV40 symmetrical RNA transcripts the RNA is processed to yield uncomplementary viral mRNA molecules.

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