Abstract
MUCH work has been directed at demonstrating the possible interaction of ethanol with levels of neurotransmitter amines or their metabolism in brain1,2. We have previously demonstrated an increase in brain levels of 5-hydroxyindoleacetic acid (5-HIAA) in mice after both a single and chronic administration of ethanol3. Our more recent work4 has focused attention on the inhibition of transport of 5-HIAA from the central nervous system (CNS) by ethanol as the factor responsible for the increase in brain 5-HIAA after ethanol. 5-HIAA diffuses from the CNS into cerebrospinal fluid (CSF), from which it is removed by a carrier-mediated transport into the bloodstream5. The effect of ethanol on transport of 5-HIAA from CSF was studied by perfusing this acid through the spinal subarachnoid space from the cisterna magna to the lumbar region of cats. This was shown to be a sensitive and reliable model for the study of transport of 5-HIAA from CSF (ref. 6).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hunt, W. A., and Majchrowicz, E., J. Neurochem., 23, 549–552, (1974).
Griffiths, P. J., Littleton, J. M., and Ortiz, A., Br. J. Pharmac., 50, 489–498 (1974).
Tabakoff, B., and Boggan, W. O., J. Neurochem., 22, 759–764 (1974).
Tabakoff, B., Ritzmann, R., and Boggan, W. O., J. Neurochem. (in the press).
Bulat, M., in Aromatic Amino Acids in the Brain, CIBA Foundation Symposium 22, (edit. by Wolstenholme, G. E. W., and FitzSimons, D. W.), 243–264 (Elsevier, North-Holland, Amsterdam, 1974).
Bulat, M., and Zivkovic, B., in Methods of Neurochemistry, 7 (edit. by Fried, R.) (Dekker, New York, in the press).
Merlis, J. K., Am. J. Physiol., 131, 67–72 (1940–41).
Bray, G. A., Analyt. Biochem., 1, 279–285 (1960).
Carlborg, F. W., Introduction to Statistics, 271–273 (Scott, Foresman and Co. 1968).
Sampath, S. S., and Neff, N. H., J. Pharmac. exp. Ther., 188, 410–414 (1974).
Ashcroft, G. W., Dow, R. C., and Moir, A. T. B., J. Physiol., Lond, 199, 397–425 (1968).
Zarcone, V., et al., Experimental Studies on Intoxication and Withdrawal (edit. by Gross, M. N.) (Plenum, New York, in the press).
Tabakoff, B., Groskopf, W., Anderson, R., and Alivisatos, S. G. A., Biochem. Pharmac., 23, 1707–1719 (1974).
Ris, M. M., and von Wartburg, J. P., Eur. J. Biochem., 37, 69–777 (1973).
Tashian, R. E., Metabolism, 10, 393–402 (1961).
Fellman, J. H., Proc. Soc. exp. Biol. Med., 93, 413–416 (1956).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
TABAKOFF, B., BULAT, M. & ANDERSON, R. Ethanol inhibition of transport of 5-hydroxyindoleacetic acid from cerebrospinal fluid. Nature 254, 708–710 (1975). https://doi.org/10.1038/254708a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/254708a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.