Abstract
A FALSE transmitter is a substance that is stored and released by a nerve terminal instead of its normal transmitter. Several false transmitters have been demonstrated at adrenergic synapses1, but there has been no report of the synthesis, storage and release of a false transmitter at cholinergic synapses. It has been suggested that the triethyl analogue of choline (2-hydroxyethyl-triethylammonium iodide, TEC) might form a cholinergic false transmitter; in vitro studies have shown that it can be accumulated by tissues that take up choline2, and that choline acetyltransferase can acetylate TEC (refs 3 and 4). Nothing is known, however, about the specificity of the processes associated with storage and release of acetylcholine in intact tissue. The possibility that TEC can form a false transmitter was studied in the present experiments. The results demonstrate the uptake of TEC, its acetylation, and the release of acetyl-TEC by the superior cervical ganglion of the cat.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Kopin, I. J., A. Rev. Pharmac., 8, 377–394 (1968).
Hemsworth, B. A., and Bosmann, H. B., Em. J. Pharmac., 16, 164–170 (1971).
Burgen, A. S. V., Burke, G., and Desbarats-Schonbaum, M. -L., Br. J. Pharmac. Chemother., 11, 308–312 (1956).
Hemsworth, B. A., and Smith, J. C., J. Neurochem., 17, 171–177 (1970).
Kibjakow, A. W., Pflügers Archs ges. Physiol., 232, 432–443 (1933).
Collier, B., and Lang, C., Can. J. Physiol. Pharmac., 47, 119–126 (1969).
Fonnum, F., Biochem. J., 113, 291–298 (1969).
Birks, R. I., and MacIntosh, F. C., Can. J. Biochem. Physiol., 39, 787–827 (1961).
Holton, P., and Ing, H. R., Br. J. Pharmac. Chemother., 4, 190–196 (1949).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
ILSON, D., COLLIER, B. Triethylcholine as a precursor to a cholinergic false transmitter. Nature 254, 618–620 (1975). https://doi.org/10.1038/254618a0
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1038/254618a0
This article is cited by
-
Formation and release of acetylpyrrolidinecholine (N-methyl, N-acetoxyethylpyrrolidinium) as a false cholinergic transmitter in the myenteric plexus of the guinea-pig small intestine
Naunyn-Schmiedeberg's Archives of Pharmacology (1977)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.