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Helper effect of normal and irradiated thymus cells on transferred immunoglobulin production


THE cellular transfer of immunoglobulin (Ig) production in mice by various lymphoid cell preparations has been demonstrated previously by the use of allotype congenic mouse strains1,2. Lymphoid cell suspensions from one mouse line are injected intravenously into histocompatible but allotype-different, partner-strain mice without deliberate immunisation, and the resulting Ig production ascertained by donor allotype analysis of the sera taken at various times. We have used this transfer system to determine whether anti-μ, pretreatment of lymphoid cells results in suppression of subsequent IgG production2, and in studies on the radiosensitivity of the B cell series (R.E.A., and N.L.W, unpublished). In analysing the results of Ig transfer in such experiments, it has become evident that the possible role of T cells in either augmenting or suppressing the Ig transfer by B cells must be determined, and here we present evidence that such T cell involvement can be demonstrated to varying degrees.

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    Herzenberg, L. A., and Warner, N. L., in Regulation of Antibody Response (edit. by Cinader, B.), 322–348 (C. C. Thomas, Illinois, 1968).

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