Abstract
DIETARY deficiency of zinc in pregnant rats causes congenital malformations of high incidence in multiple organ systems1,2. These teratogenic effects of zinc deficiency seem to be related to impairment of nucleic acid synthesis3–6. We now report that dietary zinc deficiency in the first few days of pregnancy results in abnormal cleavage and blastulation in preimplantation eggs, as early as day 3 of gestation in the rat.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Hurley, L. S., and Swenerton, H., Proc. Soc. exp. Biol. Med., 123, 692–696 (1966).
Hurley, L. S., Gowan, J., and Swenerton, H., Teratology, 4, 199–204 (1971).
Swenerton, H., Shrader, R., and Hurley, L. S., Science, 166, 1014–1015 (1969).
Sandstead, H. H., and Rinaldi, R. A., J. Cell Physiol., 73, 81 (1969).
Terhune, M. W., and Sandstead, H. H., Science, 117, 68–70 (1972).
Chesters, J. K., Trace element metabolism in animals, 2, 39–51 (University Park Press, Baltimore, 1974).
Alloiteau, J. J., and Psychoyos, A., C.r. hébd. Seanc. Acad. Sci., Paris, 262, 1561–1564 (1966).
Nicholas, J. S., The rat in laboratory investigation, 51–67 (Hafner, New York, 1942).
Wilson, J. G., Environment and birth defects, 16, 135 (Academic, New York, 1973).
Saxen, L., and Rapola, J., Congenital defects, 112–118 (Holt, Rinehart and Winston, New York, 1969).
McIntosh, J. E. A., and Lutwak-Mann, C., Biochem. J., 126, 869–876 (1972).
Dreosti, I. E., Tao, S., and Hurley, L. S. Proc. Soc. exp. Biol. Med., 128, 169–174 (1968).
Graham, C. F., The cell cycle in development and differentiation, 293–310 (Cambridge University Press, 1973).
Wilson, J. G., Harper Hosp. Bull., 24, 109–118 (1966).
Snow, M. H. L., The cell cycle in development and differentiation, 87–102 (Cambridge University Press, 1973).
Adams, C. E., Hay, M. F., and Lutwak-Mann, C. J. Embryol. exp. Morphol., 9, 468–491 (1961).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HURLEY, L., SHRADER, R. Abnormal development of preimplantation rat eggs after three days of maternal dietary zinc deficiency. Nature 254, 427–429 (1975). https://doi.org/10.1038/254427a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/254427a0
This article is cited by
-
Potential Role of Zinc in the COVID-19 Disease Process and its Probable Impact on Reproduction
Reproductive Sciences (2022)
-
Changes of the mRNA Expression Pattern of Zn Transporters: a Probable Mechanism for Cadmium Retention and Zinc Redistribution in the Suckling Rat Tissues
Biological Trace Element Research (2015)
-
Integration of spore-based genetically engineered whole-cell sensing systems into portable centrifugal microfluidic platforms
Analytical and Bioanalytical Chemistry (2010)
-
Zinc, copper and selenium in reproduction
Experientia (1994)
-
Zinc deficiency and the developing embryo
Biological Trace Element Research (1985)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
