Letter | Published:

Prevention of induced leukaemia in mice by immunological inhibition of adenohypophysis

Naturevolume 254pages334335 (1975) | Download Citation

Subjects

Abstract

THE theoretical and technical approach to an immunological inhibition of the adenonypoiphysis (AH) has been discussed in previous work1,2. It has been shown that heterologous antibodies against mouse or rat AH have high organ-specificity and affinity for acidophilic cells of the anterior pituitary gland producing growth hormone. The possible application of such an immune intervention in the prophylaxis and therapy of hormone-dependent or hormone-sensitive tumours has been suggested1 and experiments have demonstrated that hormone-dependent mammary carcinoma in rats can be prevented by anti-AH serum treatment3.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Pierpaoli, W., and Sorkin, E., Experientia, 28, 336–339 (1972).

  2. 2

    Pierpaoli, W., and Sorkin, E., Clin. exp. Immun., 11, 427–439 (1972).

  3. 3

    Pierpaoli, W., and Sorkin, E., Nature new Biol., 238, 58–59 (1972).

  4. 4

    Kaplan, H. S., J. natn. Cancer Inst., 11, 83–90 (1950).

  5. 5

    Law, L. W., and Miller, J. H., J. natn. Cancer Inst., 11, 425–438 (1950).

  6. 6

    Pierpaoli, W., Fabris, N., and Sorkin, E. Hormones and the Immune Response, Ciba Foundation Study Group No. 36 (edit. by Wolstenholme, G. E. W., and Knight, J.), 126–143 (Churchill, London, 1970).

  7. 7

    Pierpaoli, W. et al. J. natn. Cancer Inst., 53, 731–735 (1974).

  8. 8

    Pierpaoli, W., and Sorkin, E., Immunology, 16, 311–318 (1969).

  9. 9

    Haran-Ghera, N., Kotler, M., and Meshorer, A., J. natn. Cancer Inst., 39, 653–661 (1967).

  10. 10

    Haran-Ghera, N., Br. J. Cancer, 21, 739–749 (1967).

  11. 11

    Haran-Ghera, N., Nature new Biol., 246, 84–86 (1973).

Download references

Author information

Affiliations

  1. Schweizerisches Forschungsinstitut, Medizinische Abteilung, 7270, Davos-Platz, Switzerland

    • WALTER PIERPAOLI
    •  & NECHAMA HARAN-GHERA
  2. Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel

    • WALTER PIERPAOLI
    •  & NECHAMA HARAN-GHERA

Authors

  1. Search for WALTER PIERPAOLI in:

  2. Search for NECHAMA HARAN-GHERA in:

About this article

Publication history

Received

Issue Date

DOI

https://doi.org/10.1038/254334a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.