Letter | Published:

Prevention of induced leukaemia in mice by immunological inhibition of adenohypophysis

Naturevolume 254pages334335 (1975) | Download Citation



THE theoretical and technical approach to an immunological inhibition of the adenonypoiphysis (AH) has been discussed in previous work1,2. It has been shown that heterologous antibodies against mouse or rat AH have high organ-specificity and affinity for acidophilic cells of the anterior pituitary gland producing growth hormone. The possible application of such an immune intervention in the prophylaxis and therapy of hormone-dependent or hormone-sensitive tumours has been suggested1 and experiments have demonstrated that hormone-dependent mammary carcinoma in rats can be prevented by anti-AH serum treatment3.

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  1. Schweizerisches Forschungsinstitut, Medizinische Abteilung, 7270, Davos-Platz, Switzerland

  2. Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel



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