Letter | Published:

Genes required for cytotoxicity against virus-infected target cells in K and D regions of H-2 complex

Naturevolume 254pages269270 (1975) | Download Citation

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Abstract

EVIDENCE is mounting that in mice, certain specific immunological effector functions of thymus-derived (T) lymphocytes are efficient only when donors of T cells and the cells with which they interact have at least a part of the H-2 gene complex in common1–8. Examples include T helper function in vivo and in vitro1–3, cytotoxicity mediated by T cells against virus-infected4–6 or TNP-modified7 target cells in vitro, immunopathology mediated by T cells4, or protection against bacterial8 and viral infection6 in vivo. This requirement for H-2 compatibility has been studied in detail by measuring the cytotoxicity of T cells from donors immunised with either lymphocytic choriomeningitis (LCM) or ectromelia virus using target cells infected with the homologus virus.

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References

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Affiliations

  1. Department of Microbiology, John Curtin School of Medical Research, Australian National University, Canberra, ACT, 2601, Australia

    • ROBERT V. BLANDEN
    • , PETER C. DOHERTY
    • , MALCOLM B. C. DUNLOP
    • , IAN D. GARDNER
    •  & ROLF M. ZINKERNAGEL
  2. Department of Human Genetics, The University of Michigan Medical School, Ann Arbor, Michigan

    • CHELLA S. DAVID

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https://doi.org/10.1038/254269a0

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