Letter | Published:

Induced agglutinability of 3T3 mouse fibroblasts

Naturevolume 254pages247248 (1975) | Download Citation

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Abstract

CONCANAVALIN A (con A) preferentially agglutinates polyoma virus-transformed 3T3 cells (Py3T3) compared with 3T3 cells1. Brief proteolytic treatment of 3T3 cells results in agglutinability comparable with that of Py3T3 cells, and this is consistent with the suggestion that constraints at the 3T3 cell surface prevent migration and clustering of con A receptors1–3. We now report that 3T3 cells are as equally agglutinable as Py3T3 cells after a brief exposure to low ionic strength conditions (LIS, isosmotic). The data suggest that the mobility of con A receptors is altered by electrostatic interactions at the cell surface.

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Affiliations

  1. Cancer Section, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, 73104

    • JERALD J. KILLION
    •  & G. MARK KOLLMORGEN

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https://doi.org/10.1038/254247a0

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