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Positional signalling and specification of digits in chick limb morphogenesis


The interpretation of positional information can provide the basis for pattern formation in limb morphogenesis. The gradient in positional information along the antero–posterior axis, which is specified with respect to a localised boundary region, can be modified by grafting this region to successive positions along the axis. The pattern of digits obtained is consistent with a model based on diffusion of a labile morphogen and is thus similar to models proposed for the development of pattern in invertebrates.

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Tickle, C., Summerbell, D. & Wolpert, L. Positional signalling and specification of digits in chick limb morphogenesis. Nature 254, 199–202 (1975).

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