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Neurological changes in fruit bats deficient in vitamin B12

Naturevolume 254pages148150 (1975) | Download Citation

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Abstract

HAEMATOLOGICAL and neurological sequelae are the two major effects of vitamin B12 deficiency in man. In the haemopoietic system, megaloblastic change leading to anaemia seems to be caused by deranged DNA synthesis1. The cause of central nervous system demyelination, however, is unknown and progress in this area has been hampered by the lack of a suitable experimental animal model. We report that Egyptian fruit bats (Rousettus aegyptiacus), made vitamin B12 deficient in captivity, develop neurological changes similar to those observed in human subacute combined degeneration of the spinal cord.

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Affiliations

  1. Departments of Haematology and Histopathology, School of Pathology, University of the Witwatersrand and The South African Institute for Medical Research, PO Box 1038, Johannesburg, South Africa

    • RALPH GREEN
    • , SUSAN V. VAN TONDER
    • , G. JULIEN OETTLE
    • , GILLIAN COLE
    •  & JACK METZ

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https://doi.org/10.1038/254148a0

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