Letter | Published:

Separation of cells involved in phytohaemagglutinin-induced mitogenesis and cytotoxicity

Naturevolume 254pages144145 (1975) | Download Citation



LYMPHOCYTE mitogens such as phytohaemagglutinin (PHA) may induce lymphocytes to mitogenesis (DNA synthesis) and cytotoxicity (lysis of target cells). Although there is evidence that these two responses are independent of each other it remains to be determined whether different lymphocyte sub-populations are involved1,2. It has been claimed that PHA is a selective T-cell mitogen but some recent work argues against such precise specificity3. There is also evidence suggesting that PHA may induce T cells to become cytotoxic but, since non-T cells may be cytotoxic under some conditions, the situation remains to be clarified1,2,4–8.

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  1. Clinical Immunology and Immunopathology Division, Department of Pathology, University of Western Australia, Perth Medical Centre, Shenton Park, 6008, Western Australia

    • R. L. DAWKINS
    •  & P. J. ZILKO


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