Letter | Published:

Active suppressor mechanism maintaining tolerance to some self components

Naturevolume 254pages143144 (1975) | Download Citation



NORMAL mice have in their lymphoid tissues a fairly large number of cells making antibody to antigens present within isologous erythrocytes1. These plaque-forming cells (PFC) are readily seen on red blood cells (RBC) treated with bromelain, or other proteolytic enzymes1. DeHeer and Edgington2 have recently described similar PFC in NZB mice.

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    Cunningham, A. J., Nature, 252, 749 (1974).

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    DeHeer, D. H., and Edgington, T. S., Clin. exp. Immun., 16, 431 (1974).

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  1. Department of Microbiology, John Curtin School of Medical Research, PO Box 334, Canberra City, ACT, 2601, Australia



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