Letter | Published:

Active suppressor mechanism maintaining tolerance to some self components

Naturevolume 254pages143144 (1975) | Download Citation

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Abstract

NORMAL mice have in their lymphoid tissues a fairly large number of cells making antibody to antigens present within isologous erythrocytes1. These plaque-forming cells (PFC) are readily seen on red blood cells (RBC) treated with bromelain, or other proteolytic enzymes1. DeHeer and Edgington2 have recently described similar PFC in NZB mice.

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References

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    Cunningham, A. J., Nature, 252, 749 (1974).

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    DeHeer, D. H., and Edgington, T. S., Clin. exp. Immun., 16, 431 (1974).

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    Baker, P. J., Stashak, P. W., Amsbaugh, D. F., Prescott, B. & Barth, R. F., J. Immun., 105, 1581 (1970).

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    Baker, P. J., Reed, N. D., Stashak, P. W., Amsbaugh, D. F., and Prescott, B., J. exp. Med., 137, 1431 (1973).

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    Allison, A. C., Denman, A. M. & Barnes, R. D., Lancet, ii, 135 (1971).

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    Steinberg, A. D., Arthritis Rheum., 17, 11 (1974).

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    Gras, J., and Dalmau, M., Nature, 210, 430 (1966).

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Affiliations

  1. Department of Microbiology, John Curtin School of Medical Research, PO Box 334, Canberra City, ACT, 2601, Australia

    • A. J. CUNNINGHAM

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https://doi.org/10.1038/254143a0

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