Abstract
THE sensitivity of immunoassays is probably decreased by endogenous antigenic material blocking some of the antibody binding sites1. To remove antibodies generated against polypeptide hormones from endogenous antigenic material derived from the immunised animals, we took advantage of the capacity of sodium iodide to break the antigen–antibody bond.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Oster, D., Hackenthal, E., Vecsei, P., Gless, K. H., Möhring, J., and Gross, F., in Hypertension (edit. by Distler, A., and Wolff, H-P.) 62 (Georg Thieme, Stuttgart, 1973).
Freedlender, A. E., Fyhrquist, F., and Hollemans, H. J. G., in Methods of Hormone Radioimmunoassay (edit. by Jaffe, B. M., and Behrman, H. R.) 455 (Academic, New York and London, 1974).
Zettner, A., Clin. Chem., 19, 699 (1973).
Scatchard, G., Ann. N. Y. Acad. Sci., 51, 660 (1949).
Matsukara, S., West, C. D., Ichikawa, Y., Jubiz, G., Harada, G., and Tyler, F. H., J. Lab. clin. Med., 77, 490 (1971).
Arimura, A., et al., Endocrinology, 93, 1092 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FYHRQUIST, F., WALLENIUS, M. Improvement of antisera against polypeptide hormones. Nature 254, 82–83 (1975). https://doi.org/10.1038/254082a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/254082a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
