Abstract
ALTHOUGH L-dopa is the most effective therapeutic agent available for the control of the akinesia of Parkinson's disease, long term therapy may be associated with a variety of therapeutic problems1. One problem seen in some patients is a progressive loss of therapeutic response which may be associated with abnormal involuntary movements1. A state may develop in which a good response to the drug alternates with periods of akinesia and rigidity1–4. This has been called the ‘on-off’ effect or akinesia paradoxica1. While low blood levels of L-dopa may explain the onset of akinesia (‘off’ effect), this cannot explain the sudden reversal of patients' akinesia (‘on’ effect) which may occur without additional dosage of L-dopa2,3.
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References
Barbeau, A., Ann. Rev. Pharmac., 14, 91–113 (1974).
Fahn, S., Neurology, 24 (5), 431–441 (1974).
Claveria, L. E., Calne, D. B., and Allen, J. G., Br. med. J., 2, 641–643 (1973).
Cotzias, G. C., Patavasiliou, P. S., Duby, S. E., Steck, A. J., and Ginos, J. Z., Neurology, 22 (5) part 2, 82–85 (1972).
Hornykiewicz, O., Fedn Proc., 32, 183–190 (1973).
Sandier, M., Carter, S. B., Hunter, K. R., and Stern, G. M., Nature, 241, 439–443 (1973).
Turner, A. J., Baker, K. M., Algeri, S., Frigerid, A., and Garattini, S., Life Sci., 14, 2247–2257 (1974).
Sourkes, T. L., Nature, 229, 413–414 (1971).
Dougan, D. F. H., and McLean, J. R., Comp. gen. Pharmac., 1, 33–46 (1970).
Miller, R., Horn, A., and Iversen, L., Nature, 250, 238–241 (1974).
Sheppard, H., and Burghardt, C., Res. Commun. chem. path. Pharmac., 8, 527–534 (1974).
Heikkila, R., Cohen, G., and Dembiec, D., J. Pharmac. exp. Ther., 179, 150–258 (1971).
Teitel, S., O'Brien, R., and Brossi, A., J. med. Chem., 15, 845–846 (1972).
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DOUGAN, D., WADE, D. & MEARRICK, P. Effects of L-dopa metabolites at a dopamine receptor suggest a basis for ‘on-off’ effect in Parkinson's disease. Nature 254, 70–72 (1975). https://doi.org/10.1038/254070a0
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DOI: https://doi.org/10.1038/254070a0
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