Letter | Published:

Alterations in behaviour and catecholamine biosynthesis induced by lithium

Naturevolume 254pages5859 (1975) | Download Citation

Subjects

Abstract

THERE is general agreement that lithium (Li) impairs central catecholamine transmission, although the underlying mechanism is subject to debate1–4. More ambiguous is the literature describing the behavioural effects of Li in experimental animals. Although considerable evidence indicates that Li suppresses various behaviours5–10, there are reports that this effect is only apparent after drug-induced stimulation11–14. Results are also contradictory with respect to the behavioural effects of long term Li administration, some studies reporting continued or even exaggerated suppression with repeated administration15–18, while others describe development of tolerance to the Li-induced behavioural suppression12,13.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    Colburn, R. W., Goodwin, F. K., Bunney, W. E., Jr, and Davis, J. M., Nature, 215, 1395–1397 (1967).

  2. 2

    Katz, R. I., Chase, T. N., and Kopin, I. J., Science, 162, 466–467 (1968).

  3. 3

    Katz, R. I., Chase, T. N., and Kopin, I. J., J. Neurochem. 16, 961–967 (1969).

  4. 4

    Schildkraut, J. J., J. nerv. ment. Dis., 158, 348–360 (1974).

  5. 5

    Cade, J. F. J., Med. J. Aust., 2, 349–352 (1949).

  6. 6

    Weischer, M.-L., Psychopharmacologia, 15, 245–254 (1969).

  7. 7

    Sheard, M. H., Nature, 228, 284–285 (1970).

  8. 8

    Johnson, F. N., Specialia, 15, 533–535 (1972).

  9. 9

    Johnson, F. N., and Wormington, S., Nature new Biol., 235, 159–160 (1972).

  10. 10

    Smith, D. F., and Smith, H. B., Psychopharmacologia, 30, 83–88 (1973).

  11. 11

    Carroll, B. J., and Sharp, P. T., Science, 172, 1355–1357 (1971).

  12. 12

    Cox, C., Harrison-Read, P. E., Steinberg, H., and Tomkiewicz, M., Nature, 232, 336–338 (1971).

  13. 13

    Steinberg, H., Trans. Biochem. Soc., 1, 93–96 (1973).

  14. 14

    Davies, C., Sanger, D. J., Steinberg, H., and U'Prichard, D. C., Psychopharmacologia, 36, 263–274 (1974).

  15. 15

    Barratt, E. S., Creson, D. L., and Russell, G., Am. J. Psychiat., 125, 530–536 (1968).

  16. 16

    Greenspan, K., Aronoff, M. S., and Bogdanski, D. F., Pharmacology, 3, 129–136 (1970).

  17. 17

    Matussek, N., Int. Pharmacopsychiat., 6, 1770–186 (1971).

  18. 18

    Sinclair, J. D., Med. Biol., 52, 133–136 (1974).

  19. 19

    Baastrup, P. C., and Schou, M., Archs gen. Psychiat., 16, 162–172 (1967).

  20. 20

    Schou, M., in Principles of psychopharmacology (edit. by Clark, W. G., and del Giudice, J.), 653 (Academic, New York, 1970).

  21. 21

    Schou, M., Trans. Biochem. Soc., 1, 81–87 (1973).

  22. 22

    Segal, D. S., in Neurobiological mechanisms of adaptation and behaviour (edit. by Mandell, A. J.), (Raven, New York, in the press).

  23. 23

    Segal, D. S., and Mandell, A. J., Pharmac. Biochem. Behav., 2, 249–255 (1974).

  24. 24

    Segal, D. S., and Kuczenski, R., Brain Res., 68, 261–266 (1974).

  25. 25

    Nagatsu, T., Levitt, M., and Udenfriend, S., Analyt. Biochem., 9, 122–126 (1964).

  26. 26

    Kuczenski, R., J. biol. Chem., 248, 5074–5080 (1973).

  27. 27

    Corrodi, H., Fuxe, K., Hokfelt, T., and Schou, M., Psychopharmacologia, 11, 345–353 (1967).

  28. 28

    Stern, P. N., Fieve, R., Neff, N., and Costa, E., Pharmacologist, 9, 210–215 (1967).

  29. 29

    Gershon, S., Ann. Rev. Med., 23, 439–442 (1972).

  30. 30

    Segal, D. S., Kuczenski, R., and Mandell, A. J., Biol. Psychiat., 9, 147–159 (1974).

  31. 31

    Ho, A. S. K., Loh, H. H., Craves, F., Hitzemann, R. J., and Gershon, S., Eur. J. Pharmac., 10, 72–79 (1970).

  32. 32

    Friedman, E., and Gershon, S., Nature, 243, 520–521 (1973).

  33. 33

    Segal, D. S., Sullivan, J. L., III, Kuczenski, R., and Mandell, A. J., Science, 173, 847–849 (1971).

  34. 34

    Emlen, W., Segal, D. S., and Mandell, A. J., Science, 175, 79–82 (1972).

  35. 35

    Segal, D. S., Knapp, S., Kuczenski, R., and Mandell, A. J., Behav. Biol., 8, 47–53 (1973).

Download references

Author information

Affiliations

  1. Department of Psychiatry, University of California, San Diego

    • DAVID S. SEGAL
    • , MAUREEN CALLAGHAN
    •  & ARNOLD J. MANDELL
  2. Medical School, La Jolla, California, 92037

    • DAVID S. SEGAL
    • , MAUREEN CALLAGHAN
    •  & ARNOLD J. MANDELL

Authors

  1. Search for DAVID S. SEGAL in:

  2. Search for MAUREEN CALLAGHAN in:

  3. Search for ARNOLD J. MANDELL in:

About this article

Publication history

Received

Revised

Issue Date

DOI

https://doi.org/10.1038/254058a0

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.