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Initiator constitutive mutation with an ‘up-promoter’ effect in Aspergillus nidulans

Naturevolume 254pages3134 (1975) | Download Citation

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Abstract

A mutation leading to strong constitutivity for a uric acid-xanthine permease in the lower eukaryote Aspergillus nidulans has been found to be tightly linked to the putative structural gene whose expression it controls in the cis configuration. In addition, it increases the maximal induced level of transport 2.5-fold. This is the first demonstration of an initiator or promoter mutation in an eukaryote.

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    • Claudio Scazzocchio

    Present address: Department of Biology, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK

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  1. Department of Genetics, University of Cambridge, Milton Road, Cambridge, CB4 1XH, UK

    • Herbert N. Arst Jr
    •  & Claudio Scazzocchio

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https://doi.org/10.1038/254031a0

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