Abstract
STUDIES on the mouse globin mRNAs have shown that specific size classes of poly(A) exist in a population of labelled globin mRNAs (refs 1 and 2). These size classes are present in both α and β globin mRNAs (ref. 1) and the overall size of the poly(A) region in these mRNAs decreases with time1. As the three discrete size classes previously reported were observed at one labelling time, we determined whether these same size classes occur at various stages of messenger maturation, as their presence during the overall shortening process could be indicative of a specific degradatory mechanism. The presence of limiting steps in the shortening of the poly(A) region of mouse globin mRNAs is interesting in the light of possible shortening mechanisms and their relationship to poly(A) binding proteins3,4 and mRNA stability.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Get just this article for as long as you need it
$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Gorski, J., Morrison, M. R., Merkel, C. G., and Lingrel, J. B., J. molec. Biol., 86, 363–371 (1974).
Mansbridge, J. N., Crossley, J. A., Lanyon, W. G., and Williamson, R., Eur. J. Biochem., 44, 261–269 (1974).
Kwan, S-W and Brawerman, G., Proc. natn. Acad. Sci. U.S.A., 69, 3247–3250 (1972).
Blobel, G., Proc., natn. Acad. Sci. U.S.A., 70, 924–928 (1973).
Morrison, M. R., Brinkley, S. A., Gorski, J., and Lingrel, J. B., J. biol. Chem., 249, 5290–5295 (1974).
Brawerman, G., Mendecki, J., and Lee, S. Y., Biochemistry, 11, 637–641 (1972).
Morrison, M. R., Merkel, C. G., and Lingrel, J. B., Molec. biol. Rep., 1, 55–60 (1973).
Merkel, C. G., Kwan, S-P., and Lingrel, J. B., J. biol. Chem. (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
GORSKI, J., MORRISON, M., MERKEL, C. et al. Poly(A) size class distribution in globin mRNAs as a function of time. Nature 253, 749–751 (1975). https://doi.org/10.1038/253749a0
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1038/253749a0
This article is cited by
-
Roles of mRNA poly(A) tails in regulation of eukaryotic gene expression
Nature Reviews Molecular Cell Biology (2022)
-
Free cytoplasmic messenger ribonucleoprotein complexes from rabbit reticulocytes
Molecular Biology Reports (1979)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
