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Active sodium transport by mammalian urinary bladder


ALTHOUGH sodium reabsorption by the urinary bladder is important to urine formation in amphibia1–2, there have been few studies of ion movements3–7 across the mammalian bladder. If the mammalian bladder were an inert sac exhibiting only passive ion fluxes, as generally assumed, ion concentration gradients established between urine and plasma by the kidney would tend to dissipate in the bladder. We now report findings that may resolve this problem: mammalian bladder possesses, in addition to an exceptionally high electrical resistance, an aldosterone-stimulated Na+ reabsorptive mechanism.

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LEWIS, S., DIAMOND, J. Active sodium transport by mammalian urinary bladder. Nature 253, 747–748 (1975).

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