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Reactivity to tumour-associated antigens detected in mice undergoing liver regeneration


IN addition to the well-known, individually unique tumour-specific antigens in chemically induced neoplasms and the common ones in neoplasms induced by the same virus, there is evidence that neoplastic cells have antigens which are present in certain normal, syngeneic cells, but which may still be reacted against immunologically1. Most notable has been the demonstration that many tumours share antigens with normal embryonic cells2. Immunity to these antigens can be detected in various ways. It has been shown, for example, that lymphocytes from multiparous mice are cytotoxic to cultivated neoplastic but not to normal adult cells3–5 and that serum from pregnant mice can inhibit (block) this cytotoxic effect4–7.

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HELLSTROM, I., HELLSTROM, K. & NISHIOKA, M. Reactivity to tumour-associated antigens detected in mice undergoing liver regeneration. Nature 253, 744–746 (1975).

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