Abstract
CHRONICALLY splenectomised animals reflect depressed macrophage activity because the serum immunoglobulins that stimulate them, such as opsonins1–6 and leukophilic γ globulins7–8, are depressed. After splenectomy in animals receiving heterotropic autotransplants of splenic tissue, the tissue fragments (after initial necrosis) are reorganised into structures that are microscopically indistinguishable from the original spleen9–11. These reorganised explants also perform erythrophagocytosis and have been known to protect against Bartonella muris infections that are usually fatal to splenectomised rats. Furthermore, the cells from these explants can exhibit both humoral and cell-mediated immune reactions12. I report here that similar explants of autologous splenic tissue can protect against the deficient opsonin and leukophilic γ globulin activity observed in splenectomised rats.
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LIKHITE, V. Opsonin and leukophilic γ globulin in chronically splenectomised rats with and without heterotropic autotransplanted splenic tissue. Nature 253, 742–744 (1975). https://doi.org/10.1038/253742a0
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DOI: https://doi.org/10.1038/253742a0
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