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Ion movement across leukocyte plasma membrane and excitation of their metabolism

Abstract

A PERTURBATION of the molecular organisation of the surface membrane of mammalian phagocytes leads to significant modifications of their metabolism and functions1,2. These modifications include a rapid increase of oxygen uptake, of glucose oxidation by the hexose monophosphate pathway (HMP) and of hydrogen peroxide production1–3; an enhanced turnover of membrane phospholipids4 and a degranulation with extrusion of lysosomal proteins from cells5,6. The importance of this functional response of phagocytes is particularly evident when the alteration of their surface properties is caused by interaction with bacteria, which, on being engulfed, can be killed and digested by the toxic agents (for example, H2O2, superoxide anions, cationic proteins and hydrolytic enzymes) produced and/or discharged into the phagocytic vacuole6–9.

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ROMEO, D., ZABUCCHI, G., MIAMI, N. et al. Ion movement across leukocyte plasma membrane and excitation of their metabolism. Nature 253, 542–544 (1975). https://doi.org/10.1038/253542a0

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