Abstract
MAREK'S disease virus (MDV) of chickens induces lymphomas and other lymphoproliferative changes, which, depending on the virulence of the strain used, may terminate in paralysis and death. Chickens genetically selected for resistance, however, are refractory to clinical MD and most chickens that are fully susceptible when young develop resistance as they become older. Resistance acquired with age is expressed through lesion regression1,2. Our studies with genetic and age resistance established that humoral immunity did not play a major role in either type of resistance3,4 and now we present evidence that the thymus-dependent immune system is of principal importance in the natural resistance of old chickens.
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References
Witter, R. L., Sharma, J. M., Solomon, J. J., and Champion, L. R., Avian Pathol., 2, 43 (1973).
Sharma, J. M., Witter, R. L., and Burmester, B. R., Infect. Immun., 8, 715 (1973).
Sharma, J. M., Nature, 247, 117 (1974).
Sharma, J. M., and Witter, R. L., Cancer Res. (in the press).
Peterson, R. D. A., Burmester, B. R., Fredrickson, T. N., Purchase, H. G., and Good, R. A., J. natn. Cancer Inst., 32, 1343 (1964).
Cooper, M. D., Peterson, R. D. A., South, M. A., and Good, R. A., J. exp. Med., 123, 75 (1966).
Hudson, L., and Payne, L. N., Nature new Biol., 241, 52 (1973).
Rouse, B. T., Wells, R. J. H., and Warner, N. L., J. Immun., 110, 543 (1973).
Payne, L. N., and Rennie, M., J. natn. Cancer Inst., 45, 387 (1970).
Fernando, W. W. D., and Calnek, B., Avian Diseases, 15, 467 (1971).
Akiyama, Y., Kato, S., and Iwa, N., Biken J., 16, 177 (1973).
Akiyama, Y., and Kato, S., Biken J., 17, 105 (1974).
Powell, P. C., Payne, L. N., Frazier, J. A., and Rennie, M., Nature, 251, 79 (1974).
Nazerian, K., and Sharma, J. M., J. natn. Cancer Inst. (in the press).
Panigrahi, D., Waxier, G. L., and Mallman, V. H., J. Immun., 107, 289 (1971).
Peterson, R. D. A., Purchase, H. G., Burmester, B. R., Cooper, M. D., and Good, R. A., J. natn. Cancer Inst., 36, 585 (1966).
Cooper, M. D., Payne, L. N., Dent, P. B., Burmester, B. R., and Good, R. A., J. natn. Cancer Inst., 41, 373 (1968).
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SHARMA, J., WITTER, R. & PURCHASE, H. Absence of age-resistance in neonatally thymectomised chickens as evidence for cell-mediated immune surveillance in Marek's disease. Nature 253, 477–479 (1975). https://doi.org/10.1038/253477a0
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DOI: https://doi.org/10.1038/253477a0
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