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Different effector cell types in antibody-dependent cell-mediated cytotoxicity


ANTIBODY-DEPENDENT cell-mediated cytotoxicity has been demonstrated in vitro using a number of continuously cultivated cell lines1,2 and nucleated erythrocytes3 as targets. Although the biological role of this cytotoxicity is not yet clear, it represents a potentially efficient cytotoxic mechanism and considerable interest has been shown in the characterisation of the effector cells.

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SANDERSON, C., CLARK, I. & TAYLOR, G. Different effector cell types in antibody-dependent cell-mediated cytotoxicity. Nature 253, 376–377 (1975).

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