Abstract
METHYLATION of a specific nucleotide occurs at the initial stage of transcription of the double-stranded RNA genome in cytoplasmic polyhedrosis virus (CPV) in the presence of the methyl-group donor, S-adenosyl methionine (SAM)1. Methylation of mRNA has been reported recently not only for other viruses2,3 but also for a mouse L-cell4. Since methylation seems to be coupled with the initiation of mRNA synthesis in CPV, the structure of the initiation (5′) terminus of mRNA transcribed from CPV by the virus-containing RNA polymerase is of particular interest.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Furuichi, Y., Nucleic Acid Res., 1, 809–822 (1974).
Shatkin, A. J., Proc. natn. Acad. Sci. U.S.A., 71, 3204–3207 (1974).
Wei, C. M., and Moss, B., Proc. natn. Acad. Sci. U.S.A., 71, 3014–3018 (1974).
Perry, R. P., and Kelley, D. E., Cell, 1, 37–42 (1974).
Shimotohno, K., and Miura, K., Virology, 53, 283–286 (1973).
Shimotohno, K., and Miura, K., J. molec. Biol., 86, 21–30 (1974).
Miura, K., Watanabe, K., and Sugiura, M., J. molec. Biol., 86, 31–48 (1974).
Miura, K., Watanabe, K., Sugiura, M., and Shatkin, A. J., Proc. natn. Acad. Sci. U.S.A., 71, 3979–3983 (1974).
Miura, K., Fujii, I., Sakaki, T., Fuke, M., and Kawase, S., J. Virol., 2, 1211–1222 (1968).
Furuichi, Y., and Miura, K., J. molec. Biol., 64, 619–632 (1972).
Fujimoto, M. A., Kuninaka, A., and Yoshino, H., Agric. Biol., 33, 1517–1518 (1969).
Rottman, F., and Heinlein, K., Biochemistry, 7, 2634–2641 (1968).
Ro-Choi, T. S., Reddy, R., Choi, Y. C., Raj, N. B., and Henning, D., Fedn Proc., 33, 1548 (1974).
Urushibara, T., Furuichi, Y., Nishimura, C., and Miura, K., FEBS Lett (in the press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
FURUICHI, Y., MIURA, KI. A blocked structure at the 5′ terminus of mRNA from cytoplasmic polyhedrosis virus. Nature 253, 374–375 (1975). https://doi.org/10.1038/253374a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/253374a0
This article is cited by
-
Hydrogel armed with Bmp2 mRNA-enriched exosomes enhances bone regeneration
Journal of Nanobiotechnology (2023)
-
Extracellular mRNA transported to the nucleus exerts translation-independent function
Nature Communications (2021)
-
Dissolution of hypotheses in biochemistry: three case studies
History and Philosophy of the Life Sciences (2016)
-
Genome segment 5 of Antheraea mylitta cytoplasmic polyhedrosis virus encodes a bona fide guanylyltransferase
Virology Journal (2014)
-
mRNA-based therapeutics — developing a new class of drugs
Nature Reviews Drug Discovery (2014)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
