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Two biological activities regulating cell proliferation found in cultures of peritoneal exudate cells

Nature volume 253, pages 359–361 (1975)Cite this article

Abstract

WE have found two distinct biological activities in cultures of peritoneal exudate cells rich in macrophages. One consists of an inhibitory effect on cell proliferation, described previously, caused by a low molecular weight product1; the other is a stimulatory effect brought about by a non-dialysable material. Both activities were found in the same culture fluid; and different kinds of cells exhibited different sensitivities to them. Our results offer a possible explanation for the discrepancies in the literature concerning the different effects of macrophages or their products on cells1–7.

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Authors and Affiliations

  1. Department of Pathology, Harvard Medical School, Boston, Massachusetts, 02115

    JESUS CALDERON & EMIL R. UNANUE

Authors
  1. JESUS CALDERON
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  2. EMIL R. UNANUE
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CALDERON, J., UNANUE, E. Two biological activities regulating cell proliferation found in cultures of peritoneal exudate cells. Nature 253, 359–361 (1975). https://doi.org/10.1038/253359a0

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