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Nucleic acid–mutagen interactions: crystal structure of adenylyl-3′,5′-uridine plus 9-aminoacridine


Adenylyl-3′, 5′-uridine and 9-aminoacridine cocrystallise in a heavily hydrated monoclinic lattice. The adenine residues are hydrogen bonded with uracil residues and the base pairs are stacked parallel to each other in the crystal with 9-aminoacridine sandwiched directly between them.

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Seeman, N., Day, R. & Rich, A. Nucleic acid–mutagen interactions: crystal structure of adenylyl-3′,5′-uridine plus 9-aminoacridine. Nature 253, 324–326 (1975).

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