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Crystal structure of proflavine, a DNA binding agent


THE subject of DNA–small molecule binding has received much attention in recent years. Particular emphasis has been placed on aminoacridine binding1, and many studies have employed proflavine (Fig. 1) as perhaps the classical interacting agent of these series of drugs. The DNA-binding properties of proflavine cause it to act as a frameshift mutagen, and this ability has been extensively utilised in molecular genetics2.

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NEIDLE, S., JONES, T. Crystal structure of proflavine, a DNA binding agent. Nature 253, 284–285 (1975).

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