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Purification of human uterine progesterone receptor


IT is now generally accepted that before the physiological response to the androgens1, oestrogens2, glucocorticoids3 and progesterone4–7 can be manifested, these hormones must complex with specific receptors in their target tissue. Since progesterone is important both in the mechanisms associated with transport of the ovum through the oviduct8,9 and in preparing the endometrium for implantation of the blastocyst10, a greater understanding of the action of the hormone–receptor complex at the molecular level will lead to a more detailed knowledge of the mechanisms involved in reproductive biology. This understanding may be utilised to develop new contraceptive methods and to investigate the genesis and treatment of endometrial adenocarcinoma.

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SMITH, R., IRAMAIN, C., BUTTRAM, V. et al. Purification of human uterine progesterone receptor. Nature 253, 271–272 (1975).

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