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Role of growth hormone in glycosaminoglycan synthesis by articular cartilage


LITTLE is known of the factors which regulate the turnover of the glycosaminoglycans, chondroitin sulphate arid keratan sulphate, in articular cartilage. Studies using costal cartilage1 suggest that growth hormone (somatotrophin) has little direct action on glycosaminoglycan synthesis. Instead its action is thought to be mediated by the liver2 which produces a different hormone, somatomedin, previously known as ‘sulphation factor’ because it stimulates the incorporation of 35SO4 into costal cartilage.

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  1. Salmon, W. D., and Daughaday, W. E., J. lab. clin. Med., 49, 825–826 (1957).

    CAS  PubMed  Google Scholar 

  2. McConaghey, P., and Sledge, C., Nature, 225, 1249–1250 (1970).

    Article  CAS  Google Scholar 

  3. Denko, C. W., and Bergenstal, D. M., Endocrinology, 57, 76 (1955).

    Article  CAS  Google Scholar 

  4. McConaghey, P., J. Endocr., 52, 1–9 (1972).

    Article  CAS  Google Scholar 

  5. Lemperg, R. K., Bergenholtz, A., and Smith, T. W. D., In Vitro (in the press).

  6. Antonopulos, C. A., Gardell, S., Szirmai, J. A., and de Tyssonsk, R., Biochem. biophys. Acta, 83, 1–19 (1964).

    Google Scholar 

  7. Anseth, A., Antonopoulos, C. A., Bjelle, A., and Fransson L-Å., Biochim. biophys. Acta, 215, 522–526 (1970).

    Article  CAS  Google Scholar 

  8. Lemperg, R. K., Larsson, S-E., and Hjertquist, S-O., Calcified Tissue Res. (in the press).

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SMITH, T., DUCKWORTH, T., BERGENHOLTZ, A. et al. Role of growth hormone in glycosaminoglycan synthesis by articular cartilage. Nature 253, 269–271 (1975).

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